Protein secretion systems are key virulence factors of all major bacterial pathogens with an
LPS-containing outer membrane. They are also involved in complex antagonistic ecological interactions between
bacteria. We designed models and protein profiles to detect an unprecedented number and diversity (∼10000)
of bacterial protein secretion systems (T1SS, T2SS, T3SS, T4SS, T5SS, T6SSi-iii, T9SS) and evolutionarily related appendages
(T4P, Tad, Flagellum) in 1528 genomes of diderm bacteria.
The TXSScan tool is also now available.
TXSScan is freely available for systematic searches in large datasets (standalone version) or in a webserver.
The models and profiles are to be used in conjunction with MacSyFinder and MacSyView
are freely available).
The documentation on these programs can be found at http://macsyfinder.readthedocs.org/
For T3SS and Flagellar profiles:
For T4SS profiles:
The Repertoire of ICE in Prokaryotes Underscores the Unity, Diversity, and Ubiquity of Conjugation.
Key components of the eight classes of type IV secretion systems involved in bacterial conjugation or protein secretion.
Nucleic Acids Res.